Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling
نویسندگان
چکیده
منابع مشابه
Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.
After hypoxia, a critical adverse outcome is the inability to create new memories. How anterograde amnesia develops or resolves remains elusive, but a link to brain-based IL-1 is suggested due to the vital role of IL-1 in both learning and brain injury. We examined memory formation in mice exposed to acute hypoxia. After reoxygenation, memory recall recovered faster than memory formation, impac...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2019
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2019.05.025